美高美集团

林怡

林怡 副教授

职务:

电子邮件:tjlinyi@xmu.edu.cn

办公地点:

主要研究领域:

美高美集团:学习经历

2008/09—2011/06 华中科技大学同济医美高美集团,劳动卫生与环境卫生学专业;医学博士。

2005/09—2008/06 华中科技大学同济医美高美集团药美高美集团;药物分析专业;理学硕士。

2001/09—2005/06 福建医科大学药美高美集团;药学专业;理学学士。

美高美集团:工作经历

2018/10—至今,厦门大学,公共卫生美高美集团,副教授

2014/01—2018/09,中国科美高美集团城市环境研究所,城市生态健康与环境安全研究中心,副研究员

2011/07—2013/12,中国科美高美集团城市环境研究所,城市生态健康与环境安全研究中心,助理研究员

美高美集团:研究兴趣


1. 环境内分泌干扰物诱导机体代谢紊乱的毒性效应和分子机理。

2. 慢性代谢疾。2型糖尿病、脂肪肝、肥胖、肿瘤等)的表观遗传调控机制。

3. 新兴环境污染物(微塑料、大气颗粒物等)的分子毒理。

美高美集团:代表性论著(*通讯作者,?第一作者)

1.Xu Zhang?, Kai Wen?, Dongxiao Ding, Jintao Liu, Zhao Lei, Xiaoxuan Chen, Guozhu Ye, Jie Zhang, Heqing Shen, Changzhou Yan, Sijun Dong*, Qiansheng Huang*, Yi Lin*. Size-dependent adverse effects of microplastics on intestinal microbiota and metabolic homeostasis in the marine medaka (Oryzias melastigma), Environ Int, 2021,151,106452.

2.Jie Wei?, Qiongyu Hao?, Chengkun Cheng, Juan Li, Xikui Han, Zhao Lei, Tao Wang, Yinan Wang, Xiang You, Xuanxiao Chen, Huasheng Li, Yuxin Ding, Weihao Huang, Yangyang Hu, Shuirong Lin, Heqing Shen*, Yi Lin*. Epigenetic repression of miR-17 contributed to insulin resistance by targeting Keap1-Nrf2/miR-200a axis in the skeletal muscle, Theranostics, 2020,20(10):9230-9248.

3.Guozhu Ye?, Dongxiao Ding?, Han Gao, Yulang Chi, Jinsheng Chen, Zeming Wu, Yi Lin*, Sijun Dong*. Comprehensive metabolic responses of HepG2 cells to fine particulate matter exposure: Insights from an untargeted metabolomics. Sci Total Environ, 2019,691: 874-884.

4.Yulang Chi?, Hongou Wang?,Yi Lin*, Yanyang Lu, Qiansheng Huang, Guozhu Ye, Sijun Dong*. Gut microbiota characterization and lipid metabolism disorder found in PCB77-treated female mice. Toxicology, 2019, 420:11-20.

5.Yuanyuan Chen?, Yi Lin?, Peiyu Han?, Shan Jiang, Lin Che, Chengyong He, Yuchun Lin*, Zhongning Lin*. HBx combined with AFB1 triggers hepatic steatosis via COX-2-mediated necrosome formation and mitochondrial dynamics disorder. J Cell Mol Med. 2019, 23: 5920-5933.

6.Yulang Chi?, Yi Lin?, Huimin Zhu, Qiansheng Huang, Guozhu Ye, Sijun Dong. PCBs–high-fat diet interactions as mediators of gut microbiota dysbiosis and abdominal fat accumulation in female mice. Environ Pollut, 2018, 239: 332-341.

7.Yanyang Lu?, Yi Lin?,*, Dongxiao Ding, Shu Su, Qiaoqiao Chi, Youchi Zhang, Jian Sun, Xu Zhang, Huimin Zhu, Qiansheng Huang, Yulang Chi, Guozhu Ye , Shu Tao, Sijun Dong*. MiR-26a Functions as a Tumor Suppressor in Ambient Particulate Matter-bound Metals-triggered Lung Cancer Cell Metastasis by targeting LIN28B-IL6-STAT3 axis. Arch Toxicol, 2018, 92:1023-1035.

8.Jie Wei*, Dongxiao Ding, Tao Wang, Qiong Liu, Yi Lin*. MiR-338 controls BPA-triggered pancreatic islets insulin secretory dysfunction from compensation to decompensation by targeting Pdx-1. FASEB J, 2017, 31(12):5184-5195.

9.Yi Lin?, Dongxiao Ding?, Qiansheng Huang, Qiong Liu, Haoyang Lu, Yanyang Lu,Yulang Chi, Xia Sun, Guozhu Ye, Huimin Zhu, Jie Wei*, Sijun Dong*. Downregulation of miR-192 Causes Hepatic Steatosis and Lipid Accumulation by Inducing SREBF1: Novel Mechanism for Bisphenol A-triggered Non-alcoholic Fatty Liver Disease. BBA-Mol Cell Biol L, 2017, 1862(9):869-882.

10.Yanyang Lu?, Yi Lin?, Han Zhang, Dongxiao Ding, Xia Sun, Qiansheng Huang, Lifeng Lin, Ya-Jie Chen, Yu-Lang Chi, Sijun Dong*. Evaluation of Volatile Organic Compounds and Carbonyl compounds Present in Cabins of the Newly Produced, Medium- and Large-size Coaches in China. Int J Environ Res Public Health, 2016, 13(6): E596.

11.Yi Lin, Lingli Min, Qiansheng Huang, Yajie Chen, Chao Fang, Xia Sun, Sijun Dong*. The combined effects of DEHP and PCBs on phospholipase in the livers of mice. Environ Toxicol, 2015, 30(2):197-204.

12.Xia Sun?, Yi Lin?, Qiansheng Huang, Junpeng Shi, Ling Qiu, Mei Kang, Yajie Chen, Chao Fang, Ting Ye, Sijun Dong*. Di(2-ethylhexyl) Phthalate Induced INS-1 Cells Apoptosis is Dependent on Activation of Endoplasmic Reticulum Stress and Suppression of Antioxidant Protection. J Cell Mol Med, 2015,19(3): 581-594.

13.Jie Wei?, Xia Sun?, Yajie Chen, Yuanyuan Li, Liqiong Song, Zhao Zhou, Bing Xu, Yi Lin*, Shunqing Xu*. Perinatal exposure to bisphenol A exacerbates nonalcoholic steatohepatitis-like phenotype in male rat offspring fed on a high-fat diet. J Endocrinol, 2014, 22(3): 313-325.

14.Yi Lin?, Xia Sun?, Qiu Ling, Wei Jie, Huang Qiansheng, Fang Chao, Ye Ting, Kang Mei, Shen Heqing, Dong Sijun*. Exposure to bisphenol A induces dysfunction of insulin secretion and apoptosis through the damage of mitochondria in rat insulinoma (INS-1) cells. Cell Death Dis, 2013, 4: e460.

15.Yi Lin?, Jie Wei?, Yuanyuan Li, Jun Chen, Zhao Zhou, Liqiong Song, Zhengzheng Wei, Ziquan Lv, Xi Chen, Wei Xia, and Shunqing Xu*. Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat. Am J Physiol Endocrinol Metab, 2011, 301(3):E527-38.

16.Jie Wei?, Yi Lin?, Yuanyuan Li, Chenjiang Ying, Jun Chen, Liqiong Song, Zhao Zhou, Ziquan Lv, Wei Xia, Xi Chen, and Shunqing Xu*. Perinatal exposure to bisphenol A at reference dose predisposes offspring to metabolic syndrome in adult rats on a high-fat diet. Endocrinology, 2011, 152(8):3049-61.

17.Yi Lin, Yun Shi, Ming Jiang, Yuan Jin, Yan Peng, Bin Lu*, Kang Dai. Removal of phenolic estrogen pollutants from different sources of water using molecularly imprinted polymeric microspheres. Environ Pollut, 2008, 153: 483-491.

18.孙霞,林怡*,董四君*. 邻苯二甲酸二(2-乙基)己酯暴露与糖代谢紊乱相关性的研究进展, 生态毒理学报, 2014, 9(3): 413-419.

美高美集团:承担的科研项目

1.国家自然科学基金面上项目,82073505,肝细胞因子Gpnmb介导的器官间通讯在双酚A致肥胖相关乳腺癌发生中的作用和机制研究,56万元,2021/01—2021/12。

2.厦门大美高美集团长基金项目,不同粒径微塑料诱导肝脏糖脂代谢紊乱的毒性效应和分子机理研究,20720190081,75万元,2019/01—2021/12。

3.国家自然科学基金面上项目,21677140,基于microRNA探讨双酚A致肝脏糖脂代谢紊乱的分子机制及父系传代效应,66万元,2017/01—2020/12。

4.福建省自然科学基金面上项目,2017J01028,双酚A通过microRNA诱发非酒精性脂肪肝疾病发生发展的分子机制探讨,4万元,2017/04—2020/03。

5.中国科美高美集团青年创新促进会项目,2017349,80万元,2017/01—2020/12。

6.中国科美高美集团城市环境研究所青年人才领不同粒径微塑料诱导肝脏糖脂代谢紊乱的毒性效应和分子机理研究域前沿项目,IUEQN201506,微塑料及其负载的典型污染物诱导机体代谢紊乱的风险和机制研究,30万元,2016/01—2017/12。

7.国家自然科学基金青年科学基金项目,21207128,新生期DEHP暴露诱导大鼠胰岛β细胞损伤的分子机制研究,25万元,2013/01—2015/12。

8.福建省自然科学基金青年科学基金项目,2013J05033,双酚A诱导胰岛细胞氧化损伤的机制研究,3万元,2013/01—2015/12。

9.中国科美高美集团城市环境研究所青年人才领域前沿项目,IUEQN201301,慢性PM2.5暴露对机体内源性代谢物的影响及其诱发代谢紊乱相关疾病的风险研究,40万元,2013/09—2016/08。

10.宁波市自然科学基金项目,2014A610274,miRNA-192-5p在PM2.5暴露诱导肝细胞脂肪变性中的作用及机制研究,3万元,2014/02—2017/03。

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